The table below shows the treatment (which began immediately after being placed in the SD photoperiod) and testes sizes of these hamsters at the end of 12 weeks of treatment:
Group Treatment Testes size
Group 1: once every 7 days with an inert drug vehicle 5h after dark onset 0.5g (small)
Group 2: MK-801 dissolved in the vehicle 5h after dark onset 0.5g (small)
Group 3: the vehicle followed 1 hour later by a 5 minute pulse of light 3.0g (large)
Group 4: MK-801 followed 1 hour later with a 5 minute light pulse 0.5g (small)
Devise hypotheses to account for each of these 4 findings for each of the 4 groups.
Hints: MK-801 is a specific antagonist of the NMDA subclass of excitatory amino acid receptor. The light pulse was given 6 hours after the onset of darkness in the 10L:14D photoperiod.
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